Open AccessIdentification of a Proline-Kinked Amphipathic α-Helix Downstream from the Methyltransferase Domain of a Potexvirus Replicase and Its Role in Virus Replication and Perinuclear Complex Formation
Author(s) -
Ken Komatsu,
Nobumitsu Sasaki,
Tetsuya Yoshida,
Katsuhiro Suzuki,
Yuki Masujima,
Masayoshi Hashimoto,
Satoru Watanabe,
N. Tochio,
T. Kigawa,
Yutaka Yamaji,
Kenro Oshima,
Susumu Namba,
Richard S. Nelson,
Tsutomu Arie
Publication year - 2021
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.01906-20
Subject(s) - biology , rna dependent rna polymerase , rna , viral replication , biochemistry , microbiology and biotechnology , virology , virus , gene
RNA viruses characteristically associate with intracellular membranes during replication. Although virus replicases are assumed to possess membrane-targeting properties, their membrane association domains generally remain unidentified or poorly characterized.