Open AccessCoinfection of Chickens with H9N2 and H7N9 Avian Influenza Viruses Leads to Emergence of Reassortant H9N9 Virus with Increased Fitness for Poultry and a Zoonotic Potential
Author(s) -
Sushant Bhat,
Joe James,
Jean-Rémy Sadeyen,
Sahar Mahmood,
Holly Everest,
Pengxiang Chang,
Sarah K Walsh,
Alexander M. P. Byrne,
Benjamin C. Mollett,
Fabian Z. X. Lean,
Joshua E. Sealy,
Holly Shelton,
Marek J. Slomka,
Sharon M Brookes,
Munir Iqbal
Publication year - 2022
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.01856-21
Subject(s) - reassortment , biology , coinfection , virology , influenza a virus subtype h5n1 , enzootic , lineage (genetic) , h5n1 genetic structure , virus , gene , genetics , covid-19 , medicine , disease , pathology , infectious disease (medical specialty)
We evaluated the consequences of reassortment between the H7N9 and the contemporary H9N2 viruses of the G1 lineage that are enzootic in poultry across the Indian subcontinent and the Middle East. Coinfection of chickens with these viruses resulted in the emergence of novel reassortant H9N9 viruses with genes derived from both H9N2 and H7N9 viruses.