Open AccessThe N-Terminal Region of Middle East Respiratory Syndrome Coronavirus Accessory Protein 8b Is Essential for Enhanced Virulence of an Attenuated Murine Coronavirus
Author(s) -
Yuming Li,
Yingkang Jin,
Lijun Kuang,
Zhenhua Luo,
Fang Li,
Jing Sun,
Airu Zhu,
Zhen Zhuang,
Yanqun Wang,
Liyan Wen,
Donglan Liu,
Chunke Chen,
Mian Gan,
Jingxian Zhao,
Jincun Zhao
Publication year - 2022
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.01842-21
Subject(s) - biology , coronavirus , virulence , virology , middle east respiratory syndrome coronavirus , innate immune system , mouse hepatitis virus , interferon , virus , rig i , immune system , gene , immunology , genetics , medicine , disease , pathology , covid-19 , infectious disease (medical specialty)
Multiple coronaviruses (CoV) cause severe respiratory infections and become global public health threats such as SARS-CoV, MERS-CoV, and SARS-CoV-2. Each coronavirus contains different numbers of accessory proteins which show high variability among different CoVs.