Open AccessEmergence, Evolution, and Pathogenicity of Influenza A(H7N4) Virus in Shorebirds in China
Author(s) -
Hongliang Chai,
Xiang Li,
Minghui Li,
Xinru Lv,
Wentao Yu,
Yang Li,
Jing Sun,
Yulei Li,
Hui Sun,
Jingman Tian,
Yu Xu,
Xiaoli Bai,
Peng Peng,
Lin-Hong Xie,
Siyuan Qin,
Qing An,
Fengjiang Zhang,
Hailong Zhang,
Jie Du,
Siyuan Yang,
Zhijun Hou,
Xianying Zeng,
Yulong Wang,
Jüergen A. Richt,
Yajun Wang,
Yanbing Li,
Jun Ma
Publication year - 2022
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.01717-21
Subject(s) - biology , influenza a virus subtype h5n1 , flyway , phylogenetic tree , influenza a virus , virology , virus , virulence , gene , ecology , genetics , habitat
The H7 subtype avian influenza viruses, such as H7N2, H7N3, H7N4, H7N7, and H7N9, were documented as being capable of infecting humans, and the H7 subtype low pathogenicity avian influenza viruses are capable of mutating into highly pathogenic avian influenza; therefore, they pose a serious threat to public health. Here, we investigated the evolutionary history, molecular characteristics, and pathogenicity of shorebird-origin influenza A(H7N4) viruses, showing a similar evolutionary trajectory with Jiangsu human A(H7N4) viruses in HA and NA genes.