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Emergence, Evolution, and Pathogenicity of Influenza A(H7N4) Virus in Shorebirds in China
Author(s) -
Hongliang Chai,
Xiang Li,
Minghui Li,
Xinru Lv,
Wentao Yu,
Yi Li,
Jing Sun,
Yulei Li,
Heting Sun,
Jingman Tian,
Yancheng Xu,
Xiaoli Bai,
Peng Peng,
Lin-Hong Xie,
Siyuan Qin,
Qing An,
Fengjiang Zhang,
Hailong Zhang,
Jiang Du,
Siyuan Yang,
Zhijun Hou,
Xiangwei Zeng,
Yulong Wang,
Jüergen A. Richt,
Yajun Wang,
Yanbing Li,
Jianzhang Ma
Publication year - 2021
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.01717-21
Subject(s) - biology , pathogenicity , virology , virus , china , influenza a virus , microbiology and biotechnology , political science , law
The H7 subtype avian influenza viruses, such as H7N2, H7N3, H7N4, H7N7, and H7N9, were documented as being capable of infecting humans, and the H7 subtype low pathogenicity avian influenza viruses are capable of mutating into highly pathogenic avian influenza; therefore, they pose a serious threat to public health. Here, we investigated the evolutionary history, molecular characteristics, and pathogenicity of shorebird-origin influenza A(H7N4) viruses, showing a similar evolutionary trajectory with Jiangsu human A(H7N4) viruses in HA and NA genes.

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