Open AccessAltered Response Pattern following AZD5582 Treatment of SIV-Infected, ART-Suppressed Rhesus Macaque Infants
Author(s) -
Katherine M. Bricker,
Veronica Obregon-Perko,
Brianna Williams,
Danielle Oliver,
Ferzan Uddin,
Margaret Neja,
Louis B. Hopkins,
Amir Dashti,
Sherrie Jean,
Jennifer Wood,
Stephanie Ehnert,
Shan Liang,
Thomas H. Vanderford,
Gregory K. Tharp,
Steven E. Bosinger,
Amanda P. Schauer,
Maud Mavigner,
Mackenzie L. Cottrell,
David M. Margolis,
Richard M. Dunham,
Ann Chahroudi
Publication year - 2022
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.01699-21
Subject(s) - biology , viremia , dosing , cmax , rhesus macaque , immunology , pharmacokinetics , immune system , apoptosis , macaque , simian immunodeficiency virus , regimen , virology , andrology , pharmacology , virus , medicine , paleontology , biochemistry
While antiretroviral therapy (ART) has improved HIV-1 disease outcome and reduced transmission, interruption of ART results in rapid viral rebound due to the persistent latent reservoir. Interventions to reduce the viral reservoir are of critical importance, especially for children who must adhere to lifelong ART to prevent disease progression.