Open AccessEstablishment of a Monoclonal Antibody against Human NTCP That Blocks Hepatitis B Virus Infection
Author(s) -
Toshitada Takemori,
Akiko Sugimoto-Ishige,
Hironori Nishitsuji,
Yushi Futamura,
Michishige Harada,
Tomomi KimuraSomeya,
Takehisa Matsumoto,
Teruki Honma,
Miho Takana,
Masami Yaguchi,
Kyoichi Isono,
Haruhiko Koseki,
Hiroyuki Osada,
Daiki Miki,
Takashi Saito,
Takashi Tanaka,
Tatsuki Fukami,
Toshio Goto,
Mikako Shirouzu,
Kunitada Shimotohno,
Kazuaki Chayama
Publication year - 2022
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.01686-21
Subject(s) - virology , hepatitis d virus , monoclonal antibody , hepatitis b virus , biology , epitope , antibody , hepatitis b , viral replication , virus , viremia , hbsag , immunology
A number of entry inhibitors are being developed to enhance the treatment of HBV patients with oral nucleoside/nucleotide analogues (NA). To amplify the effectiveness of NA therapy, several efforts have been made to develop therapeutic MAbs with neutralizing activity against HBs antigens.