Open AccessVirus-Like Particles Containing the E2 Core Domain of Hepatitis C Virus Generate Broadly Neutralizing Antibodies in Guinea Pigs
Author(s) -
Joey McGregor,
Joshua M. Hardy,
Chan-Sien Lay,
Irene Boo,
Michael Piontek,
Manfred Suckow,
F. Coulibaly,
Pantelis Poumbourios,
Rob J. Center,
Heidi E. Drummer
Publication year - 2022
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.01675-21
Subject(s) - virology , epitope , biology , antibody , monoclonal antibody , ectodomain , antigen , neutralizing antibody , virus , glycoprotein , neutralization , virus like particle , viral entry , recombinant dna , microbiology and biotechnology , viral replication , receptor , immunology , biochemistry , gene
There is currently no vaccine to prevent hepatitis C virus infection, which affects more than 71 million people globally and is a leading cause of progressive liver disease, including cirrhosis and cancer. Broadly neutralizing antibodies that recognize the E2 envelope glycoprotein can protect against heterologous viral infection and correlate with viral clearance in humans.