Zinc Finger Protein ZFP36L1 Inhibits Flavivirus Infection by both 5′-3′ XRN1 and 3′-5′ RNA-Exosome RNA Decay Pathways | Zendy

Han C. Chiu | Zendy; Hsin-Ping Chiu | Zendy; Han-Pang Yu | Zendy; Li-Hsiung Lin | Zendy; Zih-Ping Chen | Zendy; YiLing Lin | Zendy; Ren-Jye Lin | Zendy

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Zinc Finger Protein ZFP36L1 Inhibits Flavivirus Infection by both 5′-3′ XRN1 and 3′-5′ RNA-Exosome RNA Decay Pathways

Author(s) -

Han C. Chiu,

Hsin-Ping Chiu,

Han-Pang Yu,

Li-Hsiung Lin,

Zih-Ping Chen,

YiLing Lin,

Ren-Jye Lin

Publication year - 2021

Publication title -

journal of virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.617

H-Index - 292

eISSN - 1070-6321

pISSN - 0022-538X

DOI - 10.1128/jvi.01665-21

Subject(s) - biology , rna , zinc finger , virology , rna binding protein , messenger rna , virus , untranslated region , microbiology and biotechnology , gene , genetics , transcription factor

Cellular RNA-binding proteins are among the first lines of defense against various viruses, particularly RNA viruses. ZFP36L1 belongs to the CCCH-type zinc-finger protein family and has RNA-binding activity; it has been reported to bind directly to the AU-rich elements (AREs) of a subset of cellular mRNAs and then lead to mRNA decay by recruiting mRNA-degrading enzymes.

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