Open AccessSelection of HIV Envelope Strains for Standardized Assessments of Vaccine-Elicited Antibody-Dependent Cellular Cytotoxicity-Mediating Antibodies
Author(s) -
Dieter Mielke,
Sherry Stanfield-Oakley,
Bhavesh Borate,
Leigh Fisher,
Katelyn Faircloth,
Marina Tuyishime,
Kelli Greene,
Hongmei Gao,
Carolyn Williamson,
Lynn Morris,
Christina Ochsenbauer,
Georgia D. Tomaras,
Barton F. Haynes,
David C. Montefiori,
Justin Pollara,
Allan C. deCamp,
Guido Ferrari
Publication year - 2022
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.01643-21
Subject(s) - antibody dependent cell mediated cytotoxicity , biology , vaccine trial , immunology , virology , antibody , aids vaccines , hiv vaccine , lentivirus , virus , viral disease , monoclonal antibody
Antibody-dependent cellular cytotoxicity (ADCC) responses were found to correlate with reduced risk of infection in the RV144 trial of the only human HIV-1 vaccine to show any efficacy to date. However, reagents to understand the breadth and magnitude of these responses across preclinical and clinical vaccine trials remain underdeveloped.