Open AccessRoles of ESCRT Proteins ALIX and CHMP4A and Their Interplay with Interferon-Stimulated Gene 15 during Tick-Borne Flavivirus Infection
Author(s) -
Pham-Tue-Hung Tran,
Abhilash I. Chiramel,
Magnus Johansson,
Wessam Melik
Publication year - 2022
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.01624-21
Subject(s) - escrt , biology , virology , isg15 , flavivirus , viral replication , virus , replicon , dna virus , interferon , endosome , gene , genetics , ubiquitin , genome , cell
Flaviviruses are important zoonotic viruses with high fatality rates worldwide. Here, we report that during infection the virus employs ESCRT protein members for virus replication and assembly.