Open AccessBST2 Suppresses LINE-1 Retrotransposition by Reducing the Promoter Activity of LINE-1 5′ UTR
Author(s) -
Yifei Zhao,
Juan Du,
Yu Wang,
Qing Wang,
Shaohua Wang,
Ke Zhao
Publication year - 2022
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.01610-21
Subject(s) - biology , retrotransposon , microbiology and biotechnology , innate immune system , untranslated region , rna interference , genetics , genome , gene , virology , rna , immune system , transposable element
BST2 is a potent antiviral protein that suppresses the release of several enveloped viruses, mainly by tethering the envelope of newly synthesized virions and restraining them on the surface of producer cells. In mammalian cells, there are numerous DNA elements replicating through reverse transcription, among which LINE-1 is the only retroelement that can replicate autonomously.