Analysis of B Cell Receptor Repertoires Reveals Key Signatures of the Systemic B Cell Response after SARS-CoV-2 Infection | Zendy

Yudi Zhang | Zendy; Qihong Yan | Zendy; Kun Luo | Zendy; Ping He | Zendy; Ruitian Hou | Zendy; Xinwei Zhao | Zendy; Qian Wang | Zendy; Haisu Yi | Zendy; Huan Liang | Zendy; Yijun Deng | Zendy; Fengyu Hu | Zendy; Feng Li | Zendy; Xinglong Liu | Zendy; Ying Feng | Zendy; Pingchao Li | Zendy; Linbing Qu | Zendy; Zhaoming Chen | Zendy; Qiang PanHammarström | Zendy; Liqiang Feng | Zendy; Xuefeng Niu | Zendy; Ling Chen | Zendy

Open Access

Analysis of B Cell Receptor Repertoires Reveals Key Signatures of the Systemic B Cell Response after SARS-CoV-2 Infection

Author(s) -

Yudi Zhang,

Qihong Yan,

Kun Luo,

Ping He,

Ruitian Hou,

Xinwei Zhao,

Qian Wang,

Haisu Yi,

Huan Liang,

Yijun Deng,

Fengyu Hu,

Feng Li,

Xinglong Liu,

Ying Feng,

Pingchao Li,

Linbing Qu,

Zhaoming Chen,

Qiang PanHammarström,

Liqiang Feng,

Xuefeng Niu,

Ling Chen

Publication year - 2021

Publication title -

journal of virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.617

H-Index - 292

eISSN - 1070-6321

pISSN - 0022-538X

DOI - 10.1128/jvi.01600-21

Subject(s) - biology , somatic hypermutation , antibody , virology , immunoglobulin class switching , immunology , affinity maturation , ighv@ , isotype , b cell , monoclonal antibody , immune system , germinal center , b cell receptor , chronic lymphocytic leukemia , leukemia

Although the canonical delineation of serum antibody responses following SARS-CoV-2 infection has been well established, the dynamics of antibody repertoire at the mRNA transcriptional level has not been well understood, especially the correlation between serum antibody titers and the antibody mRNA transcripts. In this study, we analyzed the IgH transcripts and characterized the B cell clonal expansion and differentiation, isotype switching, and somatic hypermutation in COVID-19 patients.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research