Open AccessAnalysis of B Cell Receptor Repertoires Reveals Key Signatures of the Systemic B Cell Response after SARS-CoV-2 Infection
Author(s) -
Yudi Zhang,
Qihong Yan,
Kun Luo,
Ping He,
Ruitian Hou,
Xiaofeng Zhao,
Qian Wang,
Haisu Yi,
Huan Liang,
YongQiang Deng,
Fengyu Hu,
Feng Li,
Xinglong Liu,
Ying Feng,
Pingchao Li,
Linbing Qu,
Zhaoming Chen,
Qiang PanHammarström,
Feng Li,
Xuefeng Niu,
Ling Chen
Publication year - 2022
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.01600-21
Subject(s) - biology , somatic hypermutation , antibody , virology , immunoglobulin class switching , immunology , ighv@ , isotype , affinity maturation , b cell , germinal center , monoclonal antibody , immune system , germline , b cell receptor , genetics , gene , chronic lymphocytic leukemia , leukemia
Although the canonical delineation of serum antibody responses following SARS-CoV-2 infection has been well established, the dynamics of antibody repertoire at the mRNA transcriptional level has not been well understood, especially the correlation between serum antibody titers and the antibody mRNA transcripts. In this study, we analyzed the IgH transcripts and characterized the B cell clonal expansion and differentiation, isotype switching, and somatic hypermutation in COVID-19 patients.