Open AccessA Panel of Kaposi’s Sarcoma-Associated Herpesvirus Mutants in the Polycistronic Kaposin Locus for Precise Analysis of Individual Protein Products
Author(s) -
Mariel Kleer,
Grant MacNeil,
Nancy Adam,
Eric S. Pringle,
Jennifer A. Corcoran
Publication year - 2022
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.01560-21
Subject(s) - biology , kaposi's sarcoma associated herpesvirus , gene , virology , locus (genetics) , viral replication , gammaherpesvirinae , genetics , virus , virus latency , mutant , rna , kaposi's sarcoma , herpesviridae , human herpesvirus , viral disease
Kaposi’s sarcoma-associated herpesvirus (KSHV) expresses high levels of the kaposin transcript during both latent and lytic phases of replication. Due to its repetitive, GC-rich nature and polycistronic coding capacity, until now no reagents existed to permit a methodical analysis of the role of individual kaposin proteins in KSHV replication.