A Panel of Kaposi’s Sarcoma-Associated Herpesvirus Mutants in the Polycistronic Kaposin Locus for Precise Analysis of Individual Protein Products | Zendy

Mariel Kleer | Zendy; Grant MacNeil | Zendy; Nancy Adam | Zendy; Eric S. Pringle | Zendy; Jennifer A. Corcoran | Zendy

Open Access

A Panel of Kaposi’s Sarcoma-Associated Herpesvirus Mutants in the Polycistronic Kaposin Locus for Precise Analysis of Individual Protein Products

Author(s) -

Mariel Kleer,

Grant MacNeil,

Nancy Adam,

Eric S. Pringle,

Jennifer A. Corcoran

Publication year - 2021

Publication title -

journal of virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.617

H-Index - 292

eISSN - 1070-6321

pISSN - 0022-538X

DOI - 10.1128/jvi.01560-21

Subject(s) - biology , locus (genetics) , mutant , genetics , messenger rna , capsid , virology , sarcoma , gene , pathology , medicine

Kaposi’s sarcoma-associated herpesvirus (KSHV) expresses high levels of the kaposin transcript during both latent and lytic phases of replication. Due to its repetitive, GC-rich nature and polycistronic coding capacity, until now no reagents existed to permit a methodical analysis of the role of individual kaposin proteins in KSHV replication.

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