Open AccessA QP509L/QP383R-Deleted African Swine Fever Virus Is Highly Attenuated in Swine but Does Not Confer Protection against Parental Virus Challenge
Author(s) -
Dan Li,
Panxue Wu,
Huanan Liu,
Feng Tian,
Wei Yang,
Yi Ru,
Li Pan,
Xiaolan Qi,
Zhengwang Shi,
Haixue Zheng
Publication year - 2022
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.01500-21
Subject(s) - african swine fever virus , biology , virology , virulence , virus , viremia , gene , biochemistry
African swine fever (ASF) is endemic to several parts of the word, with outbreaks of the disease devastating the swine farming industry; currently, no commercially available vaccine exists. Here, we report that deletion of the previously uncharacterized QP509L and QP383R viral genes completely attenuates virulence in the ASF virus (ASFV) CN/GS/2018 isolate.