A QP509L/QP383R-Deleted African Swine Fever Virus Is Highly Attenuated in Swine but Does Not Confer Protection against Parental Virus Challenge | Zendy

Dan Li | Zendy; Panxue Wu | Zendy; Huanan Liu | Zendy; Tao Feng | Zendy; Wenping Yang | Zendy; Yi Ru | Zendy; Li Pan | Zendy; Xiaolan Qi | Zendy; Zhengwang Shi | Zendy; Haixue Zheng | Zendy

Open Access

A QP509L/QP383R-Deleted African Swine Fever Virus Is Highly Attenuated in Swine but Does Not Confer Protection against Parental Virus Challenge

Author(s) -

Dan Li,

Panxue Wu,

Huanan Liu,

Tao Feng,

Wenping Yang,

Yi Ru,

Li Pan,

Xiaolan Qi,

Zhengwang Shi,

Haixue Zheng

Publication year - 2021

Publication title -

journal of virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.617

H-Index - 292

eISSN - 1070-6321

pISSN - 0022-538X

DOI - 10.1128/jvi.01500-21

Subject(s) - african swine fever virus , biology , virology , virulence , virus , viremia , gene , biochemistry

African swine fever (ASF) is endemic to several parts of the word, with outbreaks of the disease devastating the swine farming industry; currently, no commercially available vaccine exists. Here, we report that deletion of the previously uncharacterized QP509L and QP383R viral genes completely attenuates virulence in the ASF virus (ASFV) CN/GS/2018 isolate.

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