Virion Background and Efficiency of Virion Incorporation Determine Susceptibility of Simian Immunodeficiency Virus Env-Driven Viral Entry to Inhibition by IFITM Proteins | Zendy

Florian Wrensch | Zendy; Markus Hoffmann | Zendy; Sabine Gärtner | Zendy; Inga Nehlmeier | Zendy; Michael Winkler | Zendy; Stefan Pöhlmann | Zendy

Open Access

Virion Background and Efficiency of Virion Incorporation Determine Susceptibility of Simian Immunodeficiency Virus Env-Driven Viral Entry to Inhibition by IFITM Proteins

Author(s) -

Florian Wrensch,

Markus Hoffmann,

Sabine Gärtner,

Inga Nehlmeier,

Michael Winkler,

Stefan Pöhlmann

Publication year - 2016

Publication title -

journal of virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.617

H-Index - 292

eISSN - 1070-6321

pISSN - 0022-538X

DOI - 10.1128/jvi.01488-16

Subject(s) - biology , virology , viral entry , simian immunodeficiency virus , viral envelope , virus , context (archaeology) , transmembrane protein , viral replication , genetics , receptor , paleontology

Interferon-induced transmembrane proteins (IFITMs) can inhibit the cellular entry of several enveloped viruses, including simian immunodeficiency virus (SIV). The blockade of SIV by IFITMs is isolate specific, raising the question of which parameters impact sensitivity to IFITM. We show that the virion context in which SIV-Env is presented and the efficiency of virion incorporation determine Env susceptibility to inhibition by IFITMs. Thus, determinants other than the nature of the envelope protein can impact the IFITM sensitivity of viral entry.

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