TMPRSS2 Activates Hemagglutinin-Esterase Glycoprotein of Influenza C Virus
Author(s) -
Ko Sato,
Hideki Hayashi,
Yoshitaka Shimotai,
Mutsuo Yamaya,
Seiji Hongo,
Kazuyoshi Kawakami,
Yoko Matsuzaki,
Hidekazu Nishimura
Publication year - 2021
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.01296-21
Subject(s) - biology , furin , virology , tmprss2 , ns2 3 protease , neuraminidase , proteases , virus , influenza a virus , trypsin , hemagglutinin (influenza) , cleavage (geology) , protease , glycoprotein , microbiology and biotechnology , enzyme , viral replication , biochemistry , medicine , paleontology , disease , covid-19 , pathology , fracture (geology) , infectious disease (medical specialty)
Influenza C virus (ICV) is a pathogen that causes acute respiratory illness, mostly in children, but there are no anti-ICV drugs. ICV has only one kind of spike protein, the hemagglutinin-esterase (HE) glycoprotein on the virion surface, which possesses receptor-binding, receptor-destroying, and membrane fusion activities.
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