Open AccessSemi-continuous Propagation of Influenza A Virus and Its Defective Interfering Particles: Analyzing the Dynamic Competition To Select Candidates for Antiviral Therapy
Author(s) -
Lars Pelz,
Daniel Rüdiger,
Tanya Dogra,
Fadi G. Alnaji,
Yvonne Genzel,
Christopher B. Brooke,
Sascha Young Kupke,
Udo Reichl
Publication year - 2021
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.01174-21
Subject(s) - biology , virology , virus , influenza a virus , genome , small interfering rna , competition (biology) , computational biology , genetics , gene , transfection , ecology
Defective interfering particles (DIPs) emerge naturally during viral infection and typically show an internal deletion in the viral genome. Thus, DIPs are propagation-incompetent.