Open AccessSemliki Forest Virus Chimeras with Functional Replicase Modules from Related Alphaviruses Survive by Adaptive Mutations in Functionally Important Hot Spots
Author(s) -
Mona Teppor,
Eva Žusinaite,
Liis Karo-Astover,
Ailar Omler,
Kai Rausalu,
Valeria Lulla,
Aleksei Lulla,
Andres Merits
Publication year - 2021
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.00973-21
Subject(s) - semliki forest virus , biology , alphavirus , virology , togaviridae , chimera (genetics) , rna dependent rna polymerase , virus , genetics , rna , gene
Alphaviruses cause debilitating symptoms and have caused massive outbreaks. There are currently no approved antivirals or vaccines for treating these infections.
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