Open AccessCD300LF Polymorphisms of Inbred Mouse Strains Confer Resistance to Murine Norovirus Infection in a Cell Type-Dependent Manner
Author(s) -
Kevin Furlong,
Scott B. Biering,
Jayoung Choi,
Craig B. Wilen,
Robert C. Orchard,
Christiane E. Wobus,
Christopher A. Nelson,
Daved H. Fremont,
Megan T. Baldridge,
Glenn Randall,
Seungmin Hwang
Publication year - 2020
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.00837-20
Subject(s) - biology , murine norovirus , norovirus , allele , cell type , cell , virology , genetics , receptor , immunology , microbiology and biotechnology , gene , virus
MNV is a prevalent model system for studying human norovirus, which is the leading cause of gastroenteritis worldwide and thus a sizeable public health burden. Elucidating mechanisms underlying susceptibility of host cells to MNV infection can lead to insights on the roles that specific cell types play during norovirus pathogenesis. Here, we show that different alleles of the proteinaceous receptor for MNV, CD300LF, function in a cell type-dependent manner. In contrast to the C57BL/6J allele, which functions as an MNV entry factor in all tested cell types, including human cells, I/LnJ CD300LF does not function as an MNV entry factor in macrophage-like cells but does allow MNV entry in other cell types. Together, these observations indicate the existence of cell type-specific modifiers of CD300LF-dependent MNV entry.