STING Ligand-Mediated Priming of Functional CD8+T Cells Specific for HIV-1-Protective Epitopes from Naive T Cells | Zendy

Nozomi Kuse | Zendy; Tomohiro Akahoshi | Zendy; Masafumi Takiguchi | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

STING Ligand-Mediated Priming of Functional CD8⁺T Cells Specific for HIV-1-Protective Epitopes from Naive T Cells

Author(s) -

Nozomi Kuse,

Tomohiro Akahoshi,

Masafumi Takiguchi

Publication year - 2021

Publication title -

journal of virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.617

H-Index - 292

eISSN - 1070-6321

pISSN - 0022-538X

DOI - 10.1128/jvi.00699-21

Subject(s) - epitope , biology , cytotoxic t cell , priming (agriculture) , cd8 , interleukin 21 , t cell , immunology , perforin , microbiology and biotechnology , immune system , antigen , in vitro , genetics , germination , botany

The current “shock-and-kill” therapeutic strategy for HIV cure has been directed toward eliminating latent viral reservoirs by reactivation of latent reservoirs with latency-reversing agents followed by eradication of these cells by immune-mediated responses. Although HIV-1-specific T cells are expected to eradicate viral reservoirs, the function of these T cells is reduced in HIV-1-infected individuals with long-term cART.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research