Open AccessSTING Ligand-Mediated Priming of Functional CD8+T Cells Specific for HIV-1-Protective Epitopes from Naive T Cells
Author(s) -
Nozomi Kuse,
Tomohiro Akahoshi,
Masafumi Takiguchi
Publication year - 2021
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.00699-21
Subject(s) - epitope , biology , cytotoxic t cell , priming (agriculture) , cd8 , interleukin 21 , t cell , immunology , perforin , microbiology and biotechnology , immune system , antigen , in vitro , genetics , germination , botany
The current “shock-and-kill” therapeutic strategy for HIV cure has been directed toward eliminating latent viral reservoirs by reactivation of latent reservoirs with latency-reversing agents followed by eradication of these cells by immune-mediated responses. Although HIV-1-specific T cells are expected to eradicate viral reservoirs, the function of these T cells is reduced in HIV-1-infected individuals with long-term cART.