Open AccessMetabolic Syndrome and Viral Pathogenesis: Lessons from Influenza and Coronaviruses
Author(s) -
Maria A. Smith,
Rebekah Honce,
Stacey SchultzCherry
Publication year - 2020
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.00665-20
Subject(s) - biology , pathogenesis , viral pathogenesis , virus , immunology , immune system , virology , immunity , coronavirus , disease , influenza a virus , ex vivo , viral disease , in vivo , viral replication , covid-19 , infectious disease (medical specialty) , medicine , genetics , pathology
Metabolic syndrome increases the risk of severe disease due to viral infection. Yet few studies have assessed the pathogenesis of respiratory viruses in high-risk populations. Here, we summarize how metabolic dysregulation impairs immune responses, and we define the role of metabolism during influenza virus and coronavirus infections. We also discuss the use of various in vitro , in vivo , and ex vivo models to elucidate the contributions of host factors to viral susceptibility, immunity, and disease severity.