Open AccessV367F Mutation in SARS-CoV-2 Spike RBD Emerging during the Early Transmission Phase Enhances Viral Infectivity through Increased Human ACE2 Receptor Binding Affinity
Author(s) -
Junxian Ou,
Zhonghua Zhou,
Ruixue Dai,
Jing Zhang,
Shan Zhao,
Xiaowei Wu,
Wendong Lan,
Yi Ren,
Lilian Cui,
Qiaoshuai Lan,
Lu Lu,
Donald Seto,
James Chodosh,
Jianguo Wu,
Gong Zhang,
Qiwei Zhang
Publication year - 2021
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.00617-21
Subject(s) - infectivity , biology , virology , coronavirus , covid-19 , transmission (telecommunications) , betacoronavirus , pandemic , mutation , spike protein , severe acute respiratory syndrome coronavirus , viral entry , virus , viral replication , genetics , gene , infectious disease (medical specialty) , outbreak , disease , medicine , electrical engineering , pathology , engineering
A novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused the pandemic of COVID-19. The origin of SARS-CoV-2 was associated with zoonotic infections.