Open AccessPrior Heterologous Flavivirus Exposure Results in Reduced Pathogenesis in a Mouse Model of Zika Virus Infection
Author(s) -
Mariah Hassert,
Tara L. Steffen,
Stephen Scroggins,
Abigail K Coleman,
Enbal Shacham,
James D. Brien,
Amelia K. Pinto
Publication year - 2021
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.00573-21
Subject(s) - zika virus , flavivirus , dengue virus , dengue fever , virology , biology , flaviviridae , virus , antibody dependent enhancement , immunology , viral disease
The emergence and reemergence of various vector-borne diseases in recent years highlights the need to understand the mechanisms of protection for each pathogen. In this study, we investigated the impact of prior exposure to Zika virus, dengue virus serotypes 2 or 3, or the vaccine strain of yellow fever on pathogenesis and disease outcomes in a mouse model of Zika virus infection.