Open AccessCyclophilin A Inhibits Human Respiratory Syncytial Virus (RSV) Replication by Binding to RSV-N through Its PPIase Activity
Author(s) -
Wenzhang Liang,
Yue Zhang,
Miao Li,
Fadhl AlShaebi,
Jian Li,
Jing Zhang,
Lin Wei
Publication year - 2021
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.00563-21
Subject(s) - cypa , biology , cyclophilin a , viral replication , virology , virus , gene knockdown , peptidylprolyl isomerase , viral entry , cis trans isomerases , viral life cycle , capsid , microbiology and biotechnology , cell culture , gene , genetics , isomerase , biochemistry
RSV-N, packed in the viral genome to form the ribonucleoprotein (RNP) complex, which is recognized by the RSV RNA-dependent RNA polymerase (RdRp) complex to initiate viral replication and transcription, plays an indispensable role in the viral biosynthesis process. cypA, binding to RSV-N, may impair this function by weakening the interaction between RSV-N and RSV-P, thus leading to decreased viral production. Our research provides novel insight into cypA antiviral function, including binding to viral capsid protein to inhibit viral replication, which may be helpful for new antiviral drug exploration.