Open AccessCharacterization of Membrane Topology and Retention Signal of Pestiviral Glycoprotein E1
Author(s) -
Yu Mu,
Christina Radtke,
Birke Andrea Tews,
Gregor Meyers
Publication year - 2021
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.00521-21
Subject(s) - biology , er retention , transmembrane domain , transmembrane protein , membrane topology , signal peptide , endoplasmic reticulum , microbiology and biotechnology , biochemistry , virology , peptide sequence , membrane , mutant , receptor , gene
The shortage of specific antibodies against E1, making detection and further analysis of E1 difficult, resulted in a lack of knowledge on E1 compared to Erns and E2 with regard to biosynthesis, structure, and function. It is known that pestiviruses bud intracellularly.