Open AccessMovements of Ancient Human Endogenous Retroviruses Detected in SOX2-Expressing Cells
Author(s) -
Kazuaki Monde,
Yorifumi Satou,
Mizuki Goto,
Yoshikazu Uchiyama,
Jumpei Ito,
Taku Kaitsuka,
Hiromi Terasawa,
Nami Monde,
Shinya Yamaga,
Tomoya Matsusako,
Fan Yan Wei,
Ituro Inoue,
Kazuhito Tomizawa,
Akira Ono,
Takumi Era,
Tomohiro Sawa,
Yosuke Maeda
Publication year - 2022
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.00356-22
Subject(s) - biology , sox2 , induced pluripotent stem cell , retrotransposon , endogenous retrovirus , somatic cell , genome , genetics , long terminal repeat , virology , microbiology and biotechnology , embryonic stem cell , gene , transposable element
Human endogenous retroviruses (HERVs) account for approximately 8% of the human genome; however, the physiological role of HERV-K remains unknown. This study found that HERV-K LTR5Hs and LTR5B were transactivated by SOX2, which is essential for maintaining and reestablishing pluripotency.