Open AccessSequence-Function Relationships in Phage-Encoded Bacterial Cell Wall Lytic Enzymes and Their Implications for Phage-Derived Product Design
Author(s) -
Roberto Vázquez,
Ernesto García,
Pedro García
Publication year - 2021
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.00321-21
Subject(s) - lysin , lytic cycle , biology , bacteria , microbiology and biotechnology , antimicrobial , bacterial cell structure , computational biology , antimicrobial peptides , cell wall , peptidoglycan , enzyme , antibiotics , biochemistry , bacteriophage , genetics , peptide , phage display , bacteriocin , antibiotic resistance , escherichia coli , gram negative bacteria , emulation , bacterial genetics
Phage-encoded lytic enzymes, also called lysins, are one of the most promising alternatives to common antibiotics. The potential of lysins as novel antimicrobials to tackle antibiotic-resistant bacteria not only arises from features such as a lower chance to provoke resistance but also from their versatility as synthetic biology parts.
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