Open AccessSequence-Function Relationships in Phage-Encoded Bacterial Cell Wall Lytic Enzymes and Their Implications for Phage-Derived Product Design
Author(s) -
Roberto Vázquez,
Ernesto Garcı́a,
Pedro Garcı́a
Publication year - 2021
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.00321-21
Subject(s) - lysin , lytic cycle , biology , bacteriophage , phage display , genetics , antimicrobial peptides , computational biology , microbiology and biotechnology , bacteria , peptide , escherichia coli , biochemistry , gene , virus
Phage-encoded lytic enzymes, also called lysins, are one of the most promising alternatives to common antibiotics. The potential of lysins as novel antimicrobials to tackle antibiotic-resistant bacteria not only arises from features such as a lower chance to provoke resistance but also from their versatility as synthetic biology parts.