Open AccessImpact of Early ARV Initiation on Relative Proportions of Effector and Regulatory CD8 T Cell in Mesenteric Lymph Nodes and Peripheral Blood During Acute SIV Infection of Rhesus Macaques
Author(s) -
Alexis Yero,
Omar Farnós,
Julien Clain,
Ouafa Zghidi-Abouzid,
Henintsoa Rabezanahary,
Gina Racine,
Jérôme Estaquier,
MohammadAli Jenabian
Publication year - 2022
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.00255-22
Subject(s) - cd8 , biology , simian immunodeficiency virus , immunology , cytotoxic t cell , mesenteric lymph nodes , lymph , t cell , virology , virus , immune system , medicine , pathology , biochemistry , in vitro
Changes in CD8 T-cell subsets during acute SIV/HIV infections and following early ARV initiation in gut lymphoid tissues are poorly understood. Using an acute SIV infection model in rhesus macaques, we assessed the impact of early ARV, initiated 4 days postinfection, on relative proportions of CD8 T-cell subsets in MLNs compared to blood.