Open AccessPresence of Natural Killer B Cells in Simian Immunodeficiency Virus-Infected Colon That Have Properties and Functions Similar to Those of Natural Killer Cells and B Cells but Are a Distinct Cell Population
Author(s) -
Andrew Cogswell,
Sungro Jo,
Natasha Ferguson,
Kajal Gupta,
Edward Barker
Publication year - 2022
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.00235-22
Subject(s) - biology , interleukin 21 , interleukin 12 , perforin , janus kinase 3 , cytotoxic t cell , cd8 , natural killer t cell , antigen presenting cell , receptor , immunology , microbiology and biotechnology , antigen , t cell , immune system , in vitro , biochemistry
There is low-level but significant mucosal inflammation in the gastrointestinal tract secondary to human immunodeficiency virus (HIV) infection that has long-term consequences for the infected host. This inflammation most likely originates from the immune response that appears as a consequence of HIV. Here, we show in an animal model of HIV that the chronically SIV-infected gut contains cytotoxic natural killer B cells that produce inflammatory cytokines and proliferate during infection.