Open AccessCoelacanth SERINC2 Inhibits HIV-1 Infectivity and Is Counteracted by Envelope Glycoprotein from Foamy Virus
Author(s) -
Pavitra Ramdas,
Vipin Bhardwaj,
Anumeha Singh,
Nagarjun Vijay,
Ajit Chande
Publication year - 2021
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.00229-21
Subject(s) - biology , virus , infectivity , virology , viral evolution , genome , viral replication , retrovirus , genetics , virulence , evolutionary biology , gene
SERINC 5 constitutes a critical barrier to the propagation of retroviruses, as highlighted by parallel emergence of anti-SERINC5 activities among distant retroviral lineages. Therefore, understanding the origin and evolution of these host factors will provide key information about virus-host relationships that can be exploited for future drug development.