Open AccessImpact of Caveolin-Mediated Endocytosis on the Trafficking of HIV within the Colonic Barrier
Author(s) -
Alex Anwar,
Michelle Helou,
Jessica Hervol,
Alan D. Levine
Publication year - 2022
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.00202-22
Subject(s) - endocytosis , transcytosis , paracellular transport , biology , transcellular , endosome , viral entry , caveolae , microbiology and biotechnology , brefeldin a , apical membrane , intracellular , cell membrane , virology , virus , epithelium , cell , golgi apparatus , viral replication , biochemistry , membrane , signal transduction , endoplasmic reticulum , permeability (electromagnetism) , genetics
Despite the success of combination antiretroviral therapy in suppressing HIV replication and the emergence and effectiveness of PrEP-based prevention strategies, in 2018, 37,968 people in the United States received a new HIV diagnosis, accompanied by 15,820 deaths. While the annual number of new diagnoses decreased 7% from 2014 to 2018, 14% of people with HIV did not know they were infected.