Open AccessRNA Helicase A/DHX9 Forms Unique Cytoplasmic Antiviral Granules That Restrict Oncolytic Myxoma Virus Replication in Human Cancer Cells
Author(s) -
Masmudur M. Rahman,
Ami D. Gutierrez-Jensen,
Honor L. Glenn,
Mário Abrantes,
Nissin Moussatché,
Grant McFadden
Publication year - 2021
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.00151-21
Subject(s) - biology , myxoma virus , oncolytic virus , rna helicase a , virology , helicase , rna , viral replication , cytoplasm , dna , virus , microbiology and biotechnology , genetics , gene
The cellular DHX9 has both proviral and antiviral roles against diverse RNA and DNA viruses. In this article, we demonstrate that DHX9 can form unique antiviral granules in the cytoplasm during myxoma virus (MYXV) replication in human cancer cells.