Open AccessFlavivirus Envelope Protein Glycosylation: Impacts on Viral Infection and Pathogenesis
Author(s) -
Derek L. Carbaugh,
Helen M. Lazear
Publication year - 2020
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.00104-20
Subject(s) - glycosylation , biology , virology , pathogenesis , virulence , flavivirus , viral pathogenesis , viral replication , viral envelope , virus , n linked glycosylation , glycoprotein , gene , immunology , genetics , glycan
Flaviviruses encode one, two, or no N -linked glycosylation sites on their envelope proteins. Glycosylation can impact virus interactions with cell surface attachment factors and also may impact virion stability and virus replication. Envelope protein glycosylation has been identified as a virulence determinant for multiple flaviviruses, but the mechanisms by which glycosylation mediates pathogenesis remain unclear. In this Gem, we summarize current knowledge on flavivirus envelope protein glycosylation and its impact on viral infection and pathogenesis.