Open AccessPharmacological Targeting of Sphingosine Kinases Impedes HIV-1 Infection of CD4 T Cells through SAMHD1 Modulation
Author(s) -
Rachel S. Resop,
Alberto Bosque
Publication year - 2022
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.00096-22
Subject(s) - biology , sphingosine , samhd1 , sphingosine kinase , sphingosine 1 phosphate , sphingolipid , permissiveness , kinase , sphingosine kinase 1 , microbiology and biotechnology , sphingosine 1 phosphate receptor , cell culture , immunology , receptor , cancer research , viral replication , biochemistry , genetics , reverse transcriptase , rna , gene
HIV-1 infection, once established, requires lifelong treatment due to the ability of the virus to maintain latent infection in its host and become reactivated during an interruption in antiretroviral treatment (ART). Although preventing transmission and acquisition of HIV is an important goal, no ART thus far have exploited harnessing a component of the host immune system to combat transmission of the virus.