Open AccessLytic Infection with Murine Gammaherpesvirus 68 Activates Host and Viral RNA Polymerase III Promoters and Enhances Noncoding RNA Expression
Author(s) -
Ashley N. Knox,
Alice L. Mueller,
Eva M. Medina,
Eric T. Clambey,
Linda F. van Dyk
Publication year - 2021
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.00079-21
Subject(s) - biology , lytic cycle , promoter , transcription (linguistics) , rna polymerase iii , rna polymerase ii , gene expression , microbiology and biotechnology , reporter gene , rna , gene , virology , rna polymerase , virus , genetics , linguistics , philosophy
Gammaherpesviruses are a prime example of how viruses can alter the host transcriptional landscape to establish infection. Despite major insights into how these viruses modify RNA polymerase II-dependent generation of messenger RNAs, how these viruses influence the activity of host RNA polymerase III remains much less clear.