Vesicular Stomatitis Virus and DNA Vaccines Expressing Zika Virus Nonstructural Protein 1 Induce Substantial but Not Sterilizing Protection against Zika Virus Infection | Zendy

Anzhong Li | Zendy; Miaoge Xue | Zendy; Zayed Attia | Zendy; Jingyou Yu | Zendy; Mijia Lu | Zendy; Chao Shan | Zendy; Xueya Liang | Zendy; Thomas Z. Gao | Zendy; PeiYong Shi | Zendy; Mark E. Peeples | Zendy; Prosper N. Boyaka | Zendy; ShanLu Liu | Zendy; Jiànróng Lǐ | Zendy

Open Access

Vesicular Stomatitis Virus and DNA Vaccines Expressing Zika Virus Nonstructural Protein 1 Induce Substantial but Not Sterilizing Protection against Zika Virus Infection

Author(s) -

Anzhong Li,

Miaoge Xue,

Zayed Attia,

Jingyou Yu,

Mijia Lu,

Chao Shan,

Xueya Liang,

Thomas Z. Gao,

PeiYong Shi,

Mark E. Peeples,

Prosper N. Boyaka,

ShanLu Liu,

Jiànróng Lǐ

Publication year - 2020

Publication title -

journal of virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.617

H-Index - 292

eISSN - 1070-6321

pISSN - 0022-538X

DOI - 10.1128/jvi.00048-20

Subject(s) - zika virus , virology , vesicular stomatitis virus , biology , antibody , dna vaccination , virus , neutralizing antibody , antibody dependent enhancement , flavivirus , recombinant dna , immunology , dengue virus , immunization , gene , genetics

Most Zika virus (ZIKV) vaccine research has focused on the E or prM-E proteins and the induction of high levels of neutralizing antibodies. However, these ZIKV neutralizing antibodies cross-react with other flaviviruses, which may aggravate the disease via an antibody-dependent enhancement (ADE) mechanism. ZIKV NS1 protein may be an alternative antigen for vaccine development, since antibodies to NS1 do not bind to the virion, thereby eliminating the risk of ADE. Here, we show that recombinant VSV and DNA vaccines expressing NS1, alone, confer partial protection against ZIKV infection in both immunocompetent and immunodeficient mice, highlighting the value of NS1 as a potential vaccine candidate.

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