Open AccessTree Shrew Cells Transduced with Human CD4 and CCR5 Support Early Steps of HIV-1 Replication, but Viral Infectivity Is Restricted by APOBEC3
Author(s) -
Meng Luo,
Dan Mu,
Yang Xiang,
RongHua Luo,
Hong-Yi Zheng,
Min Chen,
Yingqi Guo,
YongTang Zheng
Publication year - 2021
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.00020-21
Subject(s) - biology , infectivity , virology , apobec3g , viral replication , viral entry , virus , vesicular stomatitis virus , simian immunodeficiency virus
The development of animal models is critical for studying human diseases and their pathogenesis and for evaluating drug and vaccine efficacy. For improved AIDS research, the ideal animal model of HIV-1 infection should be a small laboratory mammal that closely mimics virus replication in humans.