Mus musculus Papillomavirus 1: a New Frontier in Animal Models of Papillomavirus Pathogenesis | Zendy

Megan E. Spurgeon | Zendy; Paul F. Lambert | Zendy

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Mus musculus Papillomavirus 1: a New Frontier in Animal Models of Papillomavirus Pathogenesis

Author(s) -

Megan E. Spurgeon,

Paul F. Lambert

Publication year - 2020

Publication title -

journal of virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.617

H-Index - 292

eISSN - 1070-6321

pISSN - 0022-538X

DOI - 10.1128/jvi.00002-20

Subject(s) - biology , pathogenesis , human papillomavirus , bovine papillomavirus , virology , transmission (telecommunications) , carcinogenesis , papillomaviridae , animal model , sexual transmission , genetics , immunology , cancer , cervical cancer , gene , genome , medicine , endocrinology , electrical engineering , engineering , microbicide , human immunodeficiency virus (hiv)

Animal models of viral pathogenesis are essential tools in human disease research. Human papillomaviruses (HPVs) are a significant public health issue due to their widespread sexual transmission and oncogenic potential. Infection-based models of papillomavirus pathogenesis have been complicated by their strict species and tissue specificity. In this Gem, we discuss the discovery of a murine papillomavirus, Mus musculus papillomavirus 1 (MmuPV1), and how its experimental use represents a major advancement in models of papillomavirus-induced pathogenesis/carcinogenesis, and their transmission.

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