Open AccessMus musculus Papillomavirus 1: a New Frontier in Animal Models of Papillomavirus Pathogenesis
Author(s) -
Megan E. Spurgeon,
Paul F. Lambert
Publication year - 2020
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.00002-20
Subject(s) - biology , pathogenesis , bovine papillomavirus , human papillomavirus , virology , transmission (telecommunications) , carcinogenesis , papillomaviridae , animal model , genetics , immunology , cancer , cervical cancer , gene , genome , medicine , endocrinology , electrical engineering , engineering
Animal models of viral pathogenesis are essential tools in human disease research. Human papillomaviruses (HPVs) are a significant public health issue due to their widespread sexual transmission and oncogenic potential. Infection-based models of papillomavirus pathogenesis have been complicated by their strict species and tissue specificity. In this Gem, we discuss the discovery of a murine papillomavirus, Mus musculus papillomavirus 1 (MmuPV1), and how its experimental use represents a major advancement in models of papillomavirus-induced pathogenesis/carcinogenesis, and their transmission.