Protein characterization of Australian spotted fever group rickettsiae and monoclonal antibody typing of Rickettsia honei | Zendy

John Stenos | Zendy; Brittany N. Ross | Zendy; Feng Han | Zendy; Patricia A. Crocquet-Valdes | Zendy; David H. Walker | Zendy

Open Access

Protein characterization of Australian spotted fever group rickettsiae and monoclonal antibody typing of Rickettsia honei

Author(s) -

John Stenos,

Brittany N. Ross,

Feng Han,

Patricia A. Crocquet-Valdes,

David H. Walker

Publication year - 1997

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.35.1.261-263.1997

Subject(s) - rickettsia , antigenicity , biology , spotted fever , monoclonal antibody , virology , rickettsiales , microbiology and biotechnology , rickettsiaceae , antigen , antibody , gene , genetics , virus

Rickettsial proteins rOmp A and rOmp B exist in both Rickettsia australis and Rickettsia honei but differ in molecular weight and antigenicity; in addition, they produce distinct immunogenic responses and appear to be to conformationally dependent antigens. Species-specific monoclonal antibodies for other spotted fever group rickettsial species did not react with R. honei. A PCR product of the repeat region of the rOmp A gene from R. honei was amplified and calculated to contain 11 repeat units.

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