Examination of the Rotazyme II enzyme immunoassay for the diagnosis of rotavirus gastroenteritis | Zendy

Max Chernesky | Zendy; Santina Castriciano | Zendy; James B. Mahony | Zendy; D DeLong | Zendy

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Examination of the Rotazyme II enzyme immunoassay for the diagnosis of rotavirus gastroenteritis

Author(s) -

Max Chernesky,

Santina Castriciano,

James B. Mahony,

D DeLong

Publication year - 1985

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.22.3.462-464.1985

Subject(s) - immunoassay , rotavirus , electron microscope , rotavirus infections , virology , microscopy , chemistry , microbiology and biotechnology , biology , medicine , pathology , virus , immunology , antibody , physics , optics

Rotazyme II, which is a shorter version of Rotazyme (less than 3 h), was compared with electron microscopy and Rotazyme for sensitivity and specificity on 229 human stool specimens. Compared with electron microscopy, the newer assay was found to be 99.4% sensitive and 97.3% specific for an overall agreement of 98.7%. After resolution of discordant results by blocking tests, the Rotazyme II enzyme immunoassay was shown to be more sensitive than electron microscopy and, therefore, 100% specific.

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