Open AccessConsequences of the Edge Effect in a Commercial Enzyme-Linked Immunosorbent Assay for the Diagnosis of Lyme Neuroborreliosis
Author(s) -
Tamara van Gorkom,
Gijs H J van Arkel,
W. Voet,
Steven Thijsen,
Kristin Kremer
Publication year - 2021
Publication title -
journal of clinical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.349
H-Index - 255
eISSN - 1070-633X
pISSN - 0095-1137
DOI - 10.1128/jcm.03280-20
Subject(s) - lyme neuroborreliosis , borrelia , neuroborreliosis , antibody , immunology , medicine , borrelia burgdorferi , serology , cerebrospinal fluid , pleocytosis , biology , virology
The diagnosis of Lyme neuroborreliosis (LNB) is based on neurological symptoms, cerebrospinal fluid (CSF) pleocytosis, and intrathecally producedBorrelia -specific antibodies. In most cases, the presence of intrathecally producedBorrelia -specific antibodies is determined by using an enzyme-linked immunosorbent assay (ELISA).