Open AccessQuantitative SARS-CoV-2 Viral-Load Curves in Paired Saliva Samples and Nasal Swabs Inform Appropriate Respiratory Sampling Site and Analytical Test Sensitivity Required for Earliest Viral Detection
Author(s) -
Emily S. Savela,
Alexander Winnett,
Anna E. Romano,
Michael K. Porter,
Natasha Shelby,
Reid Akana,
Jenny Ji,
Matthew M. Cooper,
Noah W. Schlenker,
Jessica A. Reyes,
Alyssa M. Carter,
Jacob T. Barlow,
Colten Tognazzini,
Matthew Feaster,
Ying-Ying Goh,
Rustem F. Ismagilov
Publication year - 2022
Publication title -
journal of clinical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.349
H-Index - 255
eISSN - 1070-633X
pISSN - 0095-1137
DOI - 10.1128/jcm.01785-21
Subject(s) - viral load , saliva , covid-19 , virology , asymptomatic , transmission (telecommunications) , viral shedding , biology , medicine , virus , pathology , infectious disease (medical specialty) , outbreak , disease , electrical engineering , engineering
Early detection of SARS-CoV-2 infection is critical to reduce asymptomatic and presymptomatic transmission, curb the spread of variants, and maximize treatment efficacy. Low-analytical-sensitivity nasal-swab testing is commonly used for surveillance and symptomatic testing, but the ability of these tests to detect the earliest stages of infection has not been established.