The Clinical Utility of Two High-Throughput 16S rRNA Gene Sequencing Workflows for Taxonomic Assignment of Unidentifiable Bacterial Pathogens in Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry | Zendy

Hiu-Yin Lao | Zendy; Timothy Ting-Leung Ng | Zendy; Ryan Yik-Lam Wong | Zendy; Celia Sze-Ting Wong | Zendy; Lam-Kwong Lee | Zendy; Denise Wong | Zendy; Chloe Toi-Mei Chan | Zendy; Stephanie Hoi-Ching Jim | Zendy; Jake Siu-Lun Leung | Zendy; Hazel Wing-Hei Lo | Zendy; Ivan Tak-Fai Wong | Zendy; Miranda Chong-Yee Yau | Zendy; Jimmy Yiu-Wing Lam | Zendy; Alan Wu | Zendy; G. G. Siu | Zendy

Open Access

The Clinical Utility of Two High-Throughput 16S rRNA Gene Sequencing Workflows for Taxonomic Assignment of Unidentifiable Bacterial Pathogens in Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry

Author(s) -

Hiu-Yin Lao,

Timothy Ting-Leung Ng,

Ryan Yik-Lam Wong,

Celia Sze-Ting Wong,

Lam-Kwong Lee,

Denise Wong,

Chloe Toi-Mei Chan,

Stephanie Hoi-Ching Jim,

Jake Siu-Lun Leung,

Hazel Wing-Hei Lo,

Ivan Tak-Fai Wong,

Miranda Chong-Yee Yau,

Jimmy Yiu-Wing Lam,

Alan Wu,

G. G. Siu

Publication year - 2021

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.01769-21

Subject(s) - mass spectrometry , 16s ribosomal rna , biology , computational biology , microbiology and biotechnology , clinical microbiology , ribosomal rna , matrix (chemical analysis) , throughput , bacteria , chromatography , genetics , gene , chemistry , computer science , telecommunications , wireless

Bacterial pathogens that cannot be identified using matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF MS) are occasionally encountered in clinical laboratories. The 16S rRNA gene is often used for sequence-based analysis to identify these bacterial species.

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