Multicenter Evaluation of the Solana Group A Streptococcus Assay: Comparison with Culture | Zendy

Timothy S. Uphoff | Zendy; Blake W. Buchan | Zendy; Nathan A. Ledeboer | Zendy; Paul A. Granato | Zendy; Judy A. Daly | Zendy; Tara N. Marti | Zendy

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Multicenter Evaluation of the Solana Group A Streptococcus Assay: Comparison with Culture

Author(s) -

Timothy S. Uphoff,

Blake W. Buchan,

Nathan A. Ledeboer,

Paul A. Granato,

Judy A. Daly,

Tara N. Marti

Publication year - 2016

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.01268-16

Subject(s) - streptococcus , microbiology and biotechnology , streptococcaceae , group a , streptococcus pyogenes , microbiological culture , biology , multicenter study , throat culture , bacteria , medicine , genetics , staphylococcus aureus , randomized controlled trial , antibiotics

We compared group A Streptococcus (GAS) culture with a rapid helicase-dependent amplification (HDA) method using 1,082 throat swab specimens. The HDA method demonstrated 98.2% sensitivity and 97.2% specificity. GAS prevalence by culture was 20.7%, and it was 22.6% using the HDA method. In 35 min, the HDA method provided rapid, sensitive GAS detection, making culture confirmation unnecessary.

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