Characterization and Clinical Significance of Natural Variability in Hepatitis B Virus Reverse Transcriptase in Treatment-Naive Chinese Patients by Sanger Sequencing and Next-Generation Sequencing | Zendy

Ya Fu | Zendy; Yongbin Zeng | Zendy; Tianbin Chen | Zendy; Huijuan Chen | Zendy; Ni Lin | Zendy; Jinpiao Lin | Zendy; Xiaofeng Liu | Zendy; Er Huang | Zendy; Songhang Wu | Zendy; Shu Wu | Zendy; Siyi Xu | Zendy; Long Wang | Zendy; Qishui Ou | Zendy

Open Access

Characterization and Clinical Significance of Natural Variability in Hepatitis B Virus Reverse Transcriptase in Treatment-Naive Chinese Patients by Sanger Sequencing and Next-Generation Sequencing

Author(s) -

Ya Fu,

Yongbin Zeng,

Tianbin Chen,

Huijuan Chen,

Ni Lin,

Jinpiao Lin,

Xiaofeng Liu,

Er Huang,

Songhang Wu,

Shu Wu,

Siyi Xu,

Long Wang,

Qishui Ou

Publication year - 2019

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.00119-19

Subject(s) - reverse transcriptase , virology , sanger sequencing , hepatitis b virus , biology , clinical significance , hepatitis b , dna sequencing , virus , polymerase chain reaction , medicine , genetics , dna , gene

Mutations in hepatitis B virus (HBV) reverse transcriptase (RT) are associated with nucleos(t)ide analogue (NA) resistance during long-term antiviral treatment. However, the characterization of mutations in HBV RT in untreated patients has not yet been well illustrated. The objective of this study was to investigate the characterization and clinical significance of natural variability in HBV RT in treatment-naive patients.

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