Open AccessThe global regulator CsrA of Escherichia coli is a specific mRNA-binding protein
Author(s) -
Mu Ya Liu,
Tony Romeo
Publication year - 1997
Publication title -
journal of bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.652
H-Index - 246
eISSN - 1067-8832
pISSN - 0021-9193
DOI - 10.1128/jb.179.14.4639-4642.1997
Subject(s) - biology , messenger rna , regulation of gene expression , gene expression , escherichia coli , gene , regulator , recombinant dna , microbiology and biotechnology , rna binding protein , biochemistry
The csrA gene encodes a global regulatory protein which facilitates glgC mRNA decay in vivo. A purified recombinant CsrA protein was found to inhibit in vitro glg (glycogen biosynthesis) gene expression posttranscriptionally and bind specifically to a glgC runoff transcript without causing its decay. Our results provide further insight into the mechanism by which CsrA functions as an mRNA decay factor.