Open AccessRole of three chitin synthase genes in the growth of Candida albicans
Author(s) -
Toshiyuki Mio,
Tomio Yabe,
Masayuki Sudoh,
Yasuharu Satoh,
Tasuku Nakajima,
Mikio Arisawa,
Hisafumi Yamada-Okabe
Publication year - 1996
Publication title -
journal of bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.652
H-Index - 246
eISSN - 1067-8832
pISSN - 0021-9193
DOI - 10.1128/jb.178.8.2416-2419.1996
Subject(s) - chitin synthase , biology , candida albicans , chitin , microbiology and biotechnology , virulence , mutant , corpus albicans , gene , genetics , biochemistry , chitosan
The CHS2 and CHS3 genes of Candida albicans were disrupted. The double disruptant was still viable. Assessment of chitin and of calcofluor white resistance shows that CHS1 is responsible for septum formation and CHS3 is responsible for overall chitin synthesis otherwise. There were only small differences in virulence to immunocompromised mice of homozygous chs2 delta amd chs3 delta null mutants.