Open AccessThe mitogen-activated protein kinase homolog HOG1 gene controls glycerol accumulation in the pathogenic fungus Candida albicans
Author(s) -
Carmen San José,
Rebeca Alonso-Monge,
Rosa María PérezDíaz,
Jesús Pla,
César Nombela
Publication year - 1996
Publication title -
journal of bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.652
H-Index - 246
eISSN - 1067-8832
pISSN - 0021-9193
DOI - 10.1128/jb.178.19.5850-5852.1996
Subject(s) - biology , candida albicans , complementation , saccharomyces cerevisiae , mutant , protein kinase a , corpus albicans , fungal protein , gene , osmotic shock , microbiology and biotechnology , osmotic concentration , phenotype , biochemistry , kinase
The Candida albicans HOG1 gene (HOG1CA) was cloned by functional complementation of the osmosensitive phenotype associated with Saccharomyces cerevisiae hog1 delta mutants. HOG1CA codes for a 377-amino-acid protein, 78% identical to S. cerevisiae Hog1p. A C. albicans hog1 null mutant was found to be sensitive to osmotic stress and failed to accumulate glycerol on high-osmolarity media.