Open AccessThe glucose kinase gene of Streptomyces coelicolor is not required for glucose repression of the chi63 promoter
Author(s) -
C Ingram,
Janet Westpheling
Publication year - 1995
Publication title -
journal of bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.652
H-Index - 246
eISSN - 1067-8832
pISSN - 0021-9193
DOI - 10.1128/jb.177.12.3587-3588.1995
Subject(s) - streptomyces coelicolor , catabolite repression , biology , psychological repression , enzyme repression , snf3 , biochemistry , streptomyces , gene , mutant , genetics , gene expression , bacteria , saccharomyces cerevisiae
Glucose kinase is required for glucose repression of several catabolite-controlled genes in Streptomyces coelicolor and certainly plays an important role in glucose repression in these organisms. We report here that glucose kinase null mutants of S. coelicolor retain transcriptional regulation of the chitinase 63 gene, which encodes an enzyme involved in chitin utilization. Transcription of chi63 is glucose sensitive and chitin dependent. We suggest that glucose repression of chi63 is independent of glucose kinase and that there may be more than one mechanism of glucose repression in Streptomyces spp.