Open AccessThe inherent DNase of pyocin AP41 causes breakdown of chromosomal DNA
Author(s) -
Yumiko Sano
Publication year - 1993
Publication title -
journal of bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.652
H-Index - 246
eISSN - 1067-8832
pISSN - 0021-9193
DOI - 10.1128/jb.175.3.912-915.1993
Subject(s) - biology , dna , deoxyribonuclease , protein subunit , pseudomonas aeruginosa , rna , in vitro , deoxyribonuclease i , deoxyribonucleases , biochemistry , microbiology and biotechnology , bacteria , genetics , gene , base sequence
Pyocin AP41 degrades the chromosomal DNA in sensitive strains of Pseudomonas aeruginosa but has little effect on RNA, protein, and lipid syntheses. In vitro experiments showed that the carboxyl-terminal part of the large subunit of pyocin AP41 carries an inherent DNase that is responsible for its killing action.